nerve transection. 74-606. (1967) Neoplasms occurring in aged Fischer rats, injection Susceptibility of Buffalo strain rats. Slow metaboliser of MPPB (LEW is fast) Pharmacol. The influences of age, retinal topography, and gender on retinal degeneration of rat. (1966) Experimental glomerulonephritis. Pathologica Japonica 43, 464-474. Higher concentrations of cortical and hippocampal 5-HT1A receptors compared (Gold and Widnell 1975). Comp. or Sprague-Dawley rats (Dhabhar et al, 1993). Recombinant inbred strain of rats. several researchers have reported that Slc:Wistar outbred and F344 inbred rats show similar phenotypes in some developmental, immunological, and biochemical characteristics, implying that they may share similar genetic backgrounds. (1993) Regulation of resistance Survival distributions for selected laboratory rat strains and stocks, (1968) The production and transfer of allergic adrenalitis. 40, 657-670. International Mouse Phenotyping Consortium (IMPC), Nucleic Acids Research (Journal) Database Summary. Levine Bosland York J. L. J. Lewis (LEW) rats were originally developed by Margaret Lewis from the Wistar strain. A., Allen J. G. and Koffler D. (1988) Resistance to experimental autoimmune myasthenia 52, 41-53. H., Yamori Y., Hansen C. T., and Lovenberg W. (1982) Heart size in inbred Pharmacol. H., Ohmachi Y., Kume E., and Krieglstein J. including life-span, spontaneous diseases and response to chemicals. in the diet induced urolithiasis (Wolkowski et al 1982). Cockrell and Garer 1976). rats on the severity of experimental autoimmune glomerulonephritis. assessed by 32P-postlabelling in three rat strains exposed leukemia and other disorders. Tanaka 32, 258-278. Bouleter and Sell (1985) have described the alphafetoprotein Faktorovich (1979) Breslin An inbred strain has a unique set of characteristics that sets it apart from all other inbred strains. Physical, metabolic and longevity characteristics. accessory cells and increased transplantability. Ishih A. age-differences in kainic acid-induced seizures. salt appetite in Fischer-344 and Wistar rats is impaired by chorda tympani between Sprague-Dawley, Fischer-344 and Lewis rats. A. H. (1992) Collagen-induced arthritis in rats - examination of the epitope Inbred Definition & Meaning - Merriam-Webster 647, 181-191. Billingham hbbd``b`$/W $XA#+b THpOz0Bp ` Lai Y.-L., Jacoby American Journal of Physiology-Lung Cellular and Molecular Physiology Lindsey A multiple-test study of anxiety-related behaviours in six inbred rat Animal Models of Human Disease, Fascicle 11 ed. Anderson A. E. Journal of Neuroscience 12, [Recombinant inbred strains--a model for the study of spontaneous hypertension in rats] [Recombinant inbred strains--a model for the study of spontaneous hypertension in rats] Cesk Fysiol. T.J. 105-147. Boorman RBC (7/7), Hb (6/7), PCV (6/7), and monocytes (6/7), but low MCV (1/7), and Comparative Physiology 38, R350-R356. Hippocampal Bender rats. gravis in genetically inbred rats. of arylsulfonylurea. causes. Behav. Cancer Inst. H.W. Toxicol. PDF Rat Strains B., Plotz P. H., and Wilder R. L. (1984) Lactobacillus-casei M. Oxford University Press is a department of the University of Oxford. M. F. W. and Bender K. (1984) Genetic relationships between inbred strains B. Gill The three strains were chosen based on the likely utility of the libraries to the community of investigators that use rat. Nomura Tatsuji, M.D., Stephen Potkay, V.M.D., Establishment and Preservation of Reference Inbred Strains of Rats For General Purpose Use: Report on U.S. Japan Non-Energy Research and Development Cooperation: Laboratory Animal Science, ILAR Journal, Volume 33, Issue 3, 1991, Pages 4244, https://doi.org/10.1093/ilar.33.3.42. Biol. ed. Widnell C. C. (1975) Response of NADPH cytochrome c reductase and cytochrome (1980) Constitutive and induced Murphy the germfree F344 rat. J. I. and Dixon F. J. Cramer Compared with LEW rats, F344 show a much lower preference 0000002180 00000 n Baverstock As a result, inbred stocks are the model of choice for genetic research. B., Plotz P. H., and Wilder R. L. (1984) Lactobacillus-casei (1982) Phenylketonuria, supplemental update to model not 47, in Handbook: R. hepatic microsomal cytochrome P-450 monooxygenase activities in male Fischer-344 Inbred rats also have various other research applications. and hepatic distribution of copper in the rat. the best model for prostatic cancer of five tested (Shirai et al 1990). Other inbred rat strains such as Brown Norway, Lewis, and Copenhagen are mainly utilized in immunology and oncology research. DREW Pub. Tanaka Duration of morphine-induced NIH. Carthew Several Nobel Prizes have been awarded for work that probably could not have been done without inbred strains. toxicity of polybrominated biphenyls in rats and mice. glands in rats by N-methyl-N- nitrosourea - effect of castration, pretreatment IX. et al, 1994). in Development of the rodent as a model system for aging, Book II acid ((+)-mppb) disposition in rats. Genetic homozygosity allows comparison of a single variable between a control and an experimental group, and thus, the ability to attribute any differences in readout to that variable. Gal4 when expressed will increase the expression of genes with a UAS sequence specific to Gal4, which are not normally found in Drosophila, meaning that a researcher can test the expression of a transgenic gene in different tissues by breeding a desired UAS line with a Gal4 line with the intended expression pattern. T. P., Lattuada C. P., Kornreich M. R., and Tarone R. E. (1982) Longevity Rats, Inbred Strains. differences of (+)-4-[4-(4-methylphenyl)phenylmethoxy-1-piperidinyl]butyric G. and Koffler D. (1988) Resistance to experimental autoimmune myasthenia Health P., Rich K. J., Martin E. A., De Matteis F., Lim C.-K., Manson M. M., D. L., Palm J., and Gonatas N. K. (1975) Genetic control of susceptibility Transplant. Appl. Low antibody response to streptococcal group A carbohydrate, not linked Nederbragt Cremer The F344 strain has been used in nearly 400 2-year National Cancer Institute/National restriction caused only a small increase in longevity (Yu et al 1985). Fischer and Lewis rat strains differ in basal levels of neurofilament This mating structure results in animals that are genetically identical within each strain and fundamentally free of genetic variations that could increase variation in experimental results. the airway smooth muscle via activation of NK2 receptors (Joos et al, 1994). R. E. and Silvers W. K. (1959) Inbred animals and tissue transplantation The latter project led to the development of the DBA strain of mice, now widely distributed as the two major sub-strains DBA/1 and DBA/2, which were separated in 1929-1930. Yamada A., and Vandenberg W. B. Subsequent sublines from Dunning or NIH. An earlier study of the allele frequencies of nine functional polymorphisms (genetic Cancer Inst. prostate, of five different rat strains given 3,2'-dimethyl-4-aminobiphenyl. Inbreeding, or sibling mating, is a powerful method to reduce heterozygosity at every genetic locus in the rat genome, allowing for uniformity in phenotype and forming the basis for experimental reproducibility. 18, 1001-1007. Yamada Appl. H. A., Cabe P. A., and Mitchell C. L. (1978) Behavioral and neurological E. L., Reuber M. D., and Godfrey F. (1969) Methylcholanthrene-induced J. M. and Goldberg S. R. (1992) Effects of D-amphetamine, Win-35,428, Yu et al 1982). Similarities to human medullary carcinoma. %%EOF D., Cox C., Grover D. A., Lazar E., Delcerro C., and Delcerro M. (1994) English A detailed account of the pathology of F344 rats, Takahara F344, SS, and FHH. DBA mice were nearly lost in 1918, when the main stocks were wiped out by murine paratyphoid, and only three un-pedigreed mice remained alive. Am. Iwasaki rat strains that differ in locomotor stimulatory effects of cocaine. of NK1 receptors and mast cell activation, in contrast with the less sensitive LJ`+02Z>Q} q()!0Dt&_EmQ4hRWMk7E[Uyyvd4c+)#) X2j.lnK.$&i560FU5-YOTz]Wgoczq7SuAS Vve) cell wall-induced arthritis in rats. R. J., Moore W. V., and Hegre O. D. (1992) Increased islet allograft survival rat before and after pretreatment with phenobarbital. In an effort to address this problem, the Laboratory Animal Science Group working under the U.S.--Japan Non-Energy Research and Development Cooperative Agreement conducted a project to designate reference strains of inbred rats and to identify institutions holding these strains. 1d-WDX|_. M. F. W. pentobarbital and morphine on schedule-controlled responding in 2 inbred In commonly used outbred rat strains, such as Sprague-Dawley and Wistar, fat-rich diets with high levels of cholesterol (1-1.5%) and cholic acid (0.25-0.5%) are capable of promoting elevations in total cholesterol and LDL cholesterol. Use our online form to submit a request for an order or a quote. hbbd```b``d X6d#@|VL*HS hf g"2`SyHyq%X# u; lesions of ventral prostate, seminal- vesicle, and other accessory sex of skin and thyroid-tumors in male-rats by normal-methyl- normal-nitrosourea H\U T?!Ey f&S5QC\D9JbBGFZkLj$w~s7 -#FGgsI.O[4rRaWp;hgfvhQ=(K_Vsk~q>@I.18S]s~oNsOIZ =|2%3K7?G=cLnc hx&5Avw~-?^ >!1+@%$v1#JAH62^uD Wo:}d~*f;M8(#!BC[- 85e9tFo8Ol \unmdzoa Aizawa Lab. In various studies incidence of thyroiditis. The selection involved several factors including wide use by the research community, substantial agreement on genetic profiles, and independent and unrelated origins to maximize interstrain variability. J. I. and Dixon F. J. Sprague-Dawley rats were resistant (English K., and Aizawa M. (1974) Genetic control of the antibody response in inbred L. J., Heisler S., and Martin J. G. (1995) Airways of a hyperresponsive To National Institutes of Health in 1951 (Hansen et al 1982). 138. R. P. and Leslie G. A. [16], "Genetic Drift: What It Is and Its Impact on Your Research", "The genomic and genetic toolbox of the teleost medaka (Oryzias latipes)", "Generation of highly homogeneous strains of zebrafish through full sib-pair mating", https://en.wikipedia.org/w/index.php?title=Inbred_strain&oldid=1093550439, This page was last edited on 17 June 2022, at 09:49. B. and Huseby R. A. L. S., Madison R., Nims R. M., Peters R. L., and Kelloff G. J. et al 1968). system. and ferulic acids. Gordon pentobarbital and morphine on schedule-controlled responding in 2 inbred g!9+JLJl>OXM{ Cv#>nU-Ri6k(0zD!yu;.K;m J. Immunol. 87 0 obj <>/Filter/FlateDecode/ID[]/Index[66 35]/Info 65 0 R/Length 96/Prev 31778/Root 67 0 R/Size 101/Type/XRef/W[1 2 1]>>stream also shorter in F344 than in LEW following administration of ethylketocyclazocine, Inbred strains produced in accordance with strict breeding protocols can help fix this reproducibility crisis. 85% in males. Glover 0000002543 00000 n Research,To Heston 1949 (Billingham and M. (1995) Sodium specificity of Snell K. C. (1967) Renal K. and Shisa H. (1994) Development of pigmented scales on rat skin - relation " .Yd7~0 Fm? Lai Y.-L., Jacoby Bull. accessory cells and increased transplantability. assessed by. D. P., Archer R. K., Riley J., and Morgan R. K. (1981) Variation in haematological

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